The effect of Swietenia mahogani (Mahogany) seed extract on indomethacin-induced gastric ulcers in female sprague-dawley rats /
The effect of Swietenia mahogani (Mahogany) seed extract on indomethacin-induced gastric ulcers in female sprague-dawley rats /
A. Rodriguez [and eleven others]
Swietenia mahogani (mahogany) has been reported to have medicinal uses, such as treatment for hypertension, cancer, amoebiasis, chest pains and intestinal parasitism. This study examined the effect of mahogany seed extracts on indomethacin-induced gastric ulcers in female Sprague-Dawley rats. Forty five 2-3 month-old rats weighing 150-200 g were randomly assigned into 5 treatment groups, namely: [1] 5% polyvinylpyrrolidone (PVP), [2] misoprostol (144ug/kg BW), [3] 0.14g mahogany seed extract/kg BW, [4] 0.28 g mahogany seed extract/kg BW, and [5]0.57 g mahogany seed extract/kg BW. After three days of administration of treatments using gavage method, the rats were sacrificed, and their stomachs graded grossly using Bests Ulcer Staging Index. Histopathologic grading was also conducted. At the doses utilized in this study, mahogany seed extract was found to have a potential effect on the healing of gastric ulcers. It is speculated that this effect can be attributed to the phospholipid and long chain unsaturated fatty acid content of mahogany seeds. Further studies are recommended to verify these findings.
Acta Medica Philippina,1997 33 ( 3 ) pages 127-139
Stomach Ulcer
Meliaceae
Mahogany
Swietenia mahogani (mahogany) has been reported to have medicinal uses, such as treatment for hypertension, cancer, amoebiasis, chest pains and intestinal parasitism. This study examined the effect of mahogany seed extracts on indomethacin-induced gastric ulcers in female Sprague-Dawley rats. Forty five 2-3 month-old rats weighing 150-200 g were randomly assigned into 5 treatment groups, namely: [1] 5% polyvinylpyrrolidone (PVP), [2] misoprostol (144ug/kg BW), [3] 0.14g mahogany seed extract/kg BW, [4] 0.28 g mahogany seed extract/kg BW, and [5]0.57 g mahogany seed extract/kg BW. After three days of administration of treatments using gavage method, the rats were sacrificed, and their stomachs graded grossly using Bests Ulcer Staging Index. Histopathologic grading was also conducted. At the doses utilized in this study, mahogany seed extract was found to have a potential effect on the healing of gastric ulcers. It is speculated that this effect can be attributed to the phospholipid and long chain unsaturated fatty acid content of mahogany seeds. Further studies are recommended to verify these findings.
Acta Medica Philippina,1997 33 ( 3 ) pages 127-139
Stomach Ulcer
Meliaceae
Mahogany