Value of post-therapy whole body scintigraphy in predicting the need for subsequent radioactive iodine therapy in patients with well-differentiated thyroid carcinoma / (Record no. 3452)

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control field 20210312101541.0
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Title Value of post-therapy whole body scintigraphy in predicting the need for subsequent radioactive iodine therapy in patients with well-differentiated thyroid carcinoma /
Statement of responsibility, etc. Jerry M. Obaldo, Ruben V. Ogbac
520 3# - SUMMARY, ETC.
Summary, etc. INTRODUCTION: Patients with well-differentiated thyroid carcinoma (WDTC) may require more than one session of radioactive iodine therapy (RAIT). This study was conducted to determine if post-therapy whole body scintigraphy (PTWBS) can identify patients who will require repeat RAIT due to persistent disease.<br/><br/>METHOD: The records of patients with WDTC who were referred to the Philippine General Hospital for RAIT from 2005-2007 were reviewed in this retrospective cohort study. PTWBS results (number of remnants, area of remnants, and presence of metastasis) of patients who had repeat RAIT (based on laboratory and clinical evidence of persistent disease) were compared with those of patients who did not have repeat RAIT. Multiple logistic regression analysis was done.<br/><br/>RESULTS: Forty-five of 99 patients in the study [45%, 95% Confidence Interval (CI): 35 had repeat RAIT. Thirty-six of 38 patients (95%) with metastases on PTWBS required repeat RAIT, while only 9 of 61 patients (15%) with no scan evidence of metastases required subsequent therapy. Controlling for age group (age), the odds ratio was 102 (95% CI: 20 . Positive and negative predictive values were 95 and 85% respectively. The same results were obtained using metastases alone as a predictor. Twenty-six patients had extra-cervical metastases by PTWBS and all required repeat RAIT. The number and aggregate size of thyroid remnants by PTWBS, however, were not found to be predictive of the need for repeat therapy.<br/><br/>CONCLUSION: The presence of functioning metastases seen on PTWBS was highly predictive of the need for repeat RAIT.
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Linking entry complexity note Acta Medica Philippina, 2009 43 ( 4 ) pages 69-75
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Radionuclide Imaging
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Iodine
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Thyroid Neoplasms
General subdivision therapy
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Obaldo, Jerry M.
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Personal name Ogbac, Ruben V.
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Koha item type Journal Article
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Holdings
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 03/12/2021   J000138 D0001J000138 03/12/2021 03/12/2021 Journal Article