Three-month toxicity test of Philippine natural grade carrageenan in dietary administration to rats / (Record no. 3775)

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fixed length control field 03211nam a22002297a 4500
003 - CONTROL NUMBER IDENTIFIER
control field DOH
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20210325131015.0
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245 00 - TITLE STATEMENT
Title Three-month toxicity test of Philippine natural grade carrageenan in dietary administration to rats /
Statement of responsibility, etc. Oscar G. Gutierrez [and five others]
520 3# - SUMMARY, ETC.
Summary, etc. In the Philippines, carrageenan from Eucheuma seaweeds produced by the alternative refining process is known as Philippine Natural Grade (PNG) carrageenan. Philippine Natural Grade (PNG) carrageenan refined by the altenative process from Eucheuma cottonii was orally administered to male and female specific pathogen-free Sprague-Dawley rats at 0.5, 1.5 and 5.0% level admixed with the standard laboratory diet in a 3-month subchronic toxicity test. The standard laboratory diet served as the negative control and the conventionally processed refined carrageenan (CP carrageenan) admixed at 5.0% level served as the positive control diet.<br/>The average daily intake of PNG carrageenan at different mixing levels were 382, 1140 and 3887 mg/kg/day in male rats and 410, 1292 and 4170 mg/kg/day in female rats, respectively. On the other hand, the average daily intake of CP carrageenan in male and female rats were 3917 and 4249 mg/kg/day, respectively. There were no evidences observed which showed that PNG carrageenan, a high molecular weight substance, was observed at the gastrointestinal tract and no toxic manifestations or adverse effects were observed in rate as a result of ingesting PNG carrageenan for 3 months based on the clinical signs and behavioral changes, body weight gain, feed consumption and efficiency of utilization; clinical examinations, consisting of hematology, blood coagulation tests, serum biochemistry, urinalysis, and fecalysis; and pathological examinations, consisting of necropsy, organ weight and histopathology. The same findings were observed with CP carrageenan.<br/>Apparently, the principal effect induced by PNG carrageenan and CP carrageenan in rats was the passage of soft formed stools which did not have any toxic or adverse consequences. However, fecal softening with PNG carrageenan was sporadic and involved only a few rats; while with CP carrageenan, fecal softening was frequently observed in all rats. Passage of soft stool may be attributed to the laxative effect (aperient) of carrageenan. The difference in the observed frequency of fecal softening may be partially due to the presence of higher cellulose content.<br/>The absence of subchronic oral toxicity in rats at 5.0% dietary level suggests that PNG and CP carrageenan share the same toxicological attributes. Furthermore, in this toxicity test, the high cellulose content of PNG carrageenan may have contributed to the improvement of the consistency of feces excreted.(Author)
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note BFAD Laboratory Information Bulletin, 1996 2 (1) pages 20-34
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Carrageenan
General subdivision toxicity
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rats
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Gutierrez, Oscar
Titles and other words associated with a name Jr.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Alba, Ofelia M.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Calderon, Carlito J.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Pagsanhan, Evangeline P.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Molina, Helen A.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Kintanar, Quintin L.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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-- 3775
-- 3775
Holdings
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 03/25/2021   J000324 D0001J000324 03/25/2021 03/25/2021 Journal Article