Thirty-day oral toxicity effect of high-dose dextromethorphan hydrodbromide (HBr) in BFAD : SD rat (Record no. 3779)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02293nam a22002057a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DOH |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20210325141450.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210325b ||||| |||| 00| 0 eng d |
| 245 00 - TITLE STATEMENT | |
| Title | Thirty-day oral toxicity effect of high-dose dextromethorphan hydrodbromide (HBr) in BFAD : SD rat |
| Statement of responsibility, etc. | Evangeline P. Pagsanhan [and three others] |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Dextromethorphan hydrobromide (HBr) is commonly abused in the form of syrup and in combination with other drugs. There has been no long-term toxicity study that would show the effects of the drug combinations when taken in a large single doses over a prolonged period of time. In this study, a comparison was made on the effects of a high doses of fixed-dose dextromethorphan (FDD) in combination with chlorpheniramine maleate, sodium citrate and phenylpropanolamine HCl (PAA) administered orally for 30 days in BFAD:SD rat with plain dextromethorphan (PD) in 60% sucrose. The test rats were allowed to recover for 7 days post-30 days treatment. Different parameters, such as animal observation, body weight, water and feed intakes, urinalysis, hematology, serum biochemistry, and gross pathology were used to compare baseline data and cumulative effects of FDD and PD. The results of the experiment showed manifestation of generalized pilomotor erection of all male and female rats administered with FDD which was not observed during the recovery period. One of the female subjects manifested bilateral nephromegaly with hydronephrosis. The generalized pilomotor erection is attributed to the symphathomimetic effect of PAA, an alpha-adrenergic agonist, on the smooth muscles of the roots of the hair. The bilateral nehpromegaly with hydronephrosis may be attributed to the sensitivity of the rat to PAA. Dextromethorphan HBr in combination with PAA administered over a prolonged period of time at high doses can induce nephromegaly with hydronephrosis in sensitive rats.(Author) |
| 580 ## - LINKING ENTRY COMPLEXITY NOTE | |
| Linking entry complexity note | BFAD Laboratory Information Bulletin, 1996 2 (1) pages 1-5 |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dextromethorphan |
| General subdivision | toxicity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Dextromethorphan Hydrobromide -- toxicity |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pagsanhan, Evangeline P. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gutierrez, Oscar |
| Titles and other words associated with a name | Jr. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Biares, Caroline Imelda B. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Calderon, Carlito J. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 999 ## - | |
| -- | 3779 |
| -- | 3779 |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| National Library of Medicine | DOH Central Library | DOH Central Library | Electronic Resource Section | 03/25/2021 | J000328 | D0001J000328 | 03/25/2021 | 03/25/2021 | Journal Article |