Determination of rifampicin in human plasma by reversed-phase liquid chromatography / (Record no. 3785)

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fixed length control field 01782nam a22002057a 4500
003 - CONTROL NUMBER IDENTIFIER
control field DOH
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20210325164301.0
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fixed length control field 210325b ||||| |||| 00| 0 eng d
245 00 - TITLE STATEMENT
Title Determination of rifampicin in human plasma by reversed-phase liquid chromatography /
Statement of responsibility, etc. Maria Lourdes C. Santiago [and three others]
520 3# - SUMMARY, ETC.
Summary, etc. A simple, specific and sensitive high pressure liquid chromatographic method for the determination of rifampicin in human plasma of Filipino male and female healthy volunteers was developed and validated<br/>This method utilizes a direct precipitation separation technique and ultraviolet detection monitored at 337 nm. Dipyridamole is used as the internal standard. Rifampicin and the internal standard were separated using a Bakerbond narrow pore octyl (C8, 5um, 120 A, 4.6 x 250 nm) reversed-phase column with 10 mM phosphate buffer (pH 5.2), acetonitrile, and tetrahydrofuran (65:35:10) as the mobile phase. The retention time was 7.7 minutes for rifampicin and 14.5 minutes for dipyridamole. Results showed a linear response in the concentraion range of 0.5 to 20 mg/L (r=0.99925). The limit of quantitation is 0.5 mg/L. Both intraday and interday accuracy and precision data showed good reproducibility.<br/>The precision, accuracy, linearity, specificity, and sensitivity of the method were well-within the range of clinical utility and meet the requirements for bioavailability, bioequivalence, and pharmacokinetic studies.(Author)
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note BFAD Laboratory Information Bulletin, 1997 3 (1) pages 30-35
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rifampin
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Plasma
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Santiago, Maria Lourdes C.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Gonzales, Therese Irynne R.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sarau, Josephine K.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Abejo, Vivianne O.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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-- 3785
-- 3785
Holdings
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 03/25/2021   J000334 D0001J000334 03/25/2021 03/25/2021 Journal Article