Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge / (Record no. 3787)
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| fixed length control field | 04233nam a22008057a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DOH |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20210326105912.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210326b ||||| |||| 00| 0 eng d |
| 245 00 - TITLE STATEMENT | |
| Title | Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge / |
| Statement of responsibility, etc. | Betty Raman [forty nine others] |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Background: The medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality of life and mental health are poorly understood.<br/><br/>Methods: Fifty-eight COVID-19 patients post-hospital discharge and 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver and kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary exercise test (CPET), quality of life, cognitive and mental health assessments.<br/><br/>Findings: At 2-3 months from disease-onset, 64% of patients experienced breathlessness and 55% reported fatigue. On MRI, abnormalities were seen in lungs (60%), heart (26%), liver (10%) and kidneys (29%). Patients exhibited changes in the thalamus, posterior thalamic radiations and sagittal stratum on brain MRI and demonstrated impaired cognitive performance, specifically in the executive and visuospatial domains. Exercise tolerance (maximal oxygen consumption and ventilatory efficiency on CPET) and six-minute walk distance were significantly reduced. The extent of extra-pulmonary MRI abnormalities and exercise intolerance correlated with serum markers of inflammation and acute illness severity. Patients had a higher burden of self-reported symptoms of depression and experienced significant impairment in all domains of quality of life compared to controls (p<0.0001 to 0.044).<br/><br/>Interpretation: A significant proportion of patients discharged from hospital reported symptoms of breathlessness, fatigue, depression and had limited exercise capacity. Persistent lung and extra-pulmonary organ MRI findings are common in patients and linked to inflammation and severity of acute illness. |
| 580 ## - LINKING ENTRY COMPLEXITY NOTE | |
| Linking entry complexity note | EClinicalMedicine, 2021 Jan 7;31:100683. <br/>doi: 10.1016/j.eclinm.2020.100683 |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | COVID-19 |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Coronavirus |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Magnetic Resonance Imaging |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mental Health |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Survivors |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Multiorgan Effects |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Raman, Betty |
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| Personal name | Cassar, Mark Philip |
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| Personal name | Tunnicliffe, Elizabeth M. |
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| Personal name | Filippini, Nicola |
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| Personal name | Griffanti, Ludovica |
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| Personal name | Alfaro-Almagro, Fidel |
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| Personal name | Okell, Thomas |
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| Personal name | Sheerin, Fintan |
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| Personal name | Xie, Cheng |
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| Personal name | Mahmod, Masliza |
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| Personal name | Moze, Ferenc E. |
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| Personal name | Lewandowski, Adam J. |
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| Personal name | Ohuma, Eric O. |
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| Personal name | Holdsworth, David |
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| Personal name | Lamlum, Hanan |
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| Personal name | Woodman, Myles J. |
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| Personal name | Krasopoulos, Catherine |
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| Personal name | Mills, Rebecca |
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| Personal name | McConnell, Flora A. Kennedy |
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| Personal name | Wang, Chaoyue |
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| Personal name | Arthofer, Christoph |
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| Personal name | Lange, Frederik J. |
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| Personal name | Andersson, Jesper |
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| Personal name | Jenkinson, Mark |
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| Personal name | Antoniades, Charalambos |
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| Personal name | Channon, Keith M. |
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| Personal name | Shanmuganathan, Mayooran |
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| Personal name | Ferreira, Vanessa M. |
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| Personal name | Piechnik, Stefan K. |
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| Personal name | Klenerman, Paul |
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| Personal name | Brightling, Christopher |
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| Personal name | Talbot, Nick P. |
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| Personal name | Petousik, Nayia |
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| Personal name | Rahman, Najib M. |
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| Personal name | Hom, Ling-Pei |
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| Personal name | Saunders, Kate |
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| Personal name | Geddes, John R. |
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| Personal name | Harrison, Paul J. |
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| Personal name | Pattinsono, Kyle |
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| Personal name | Rowlando, Matthew J. |
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| Personal name | Angus, Brian J. |
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| Personal name | Gleeson, Fergus |
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| Personal name | Pavlides, Michael |
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| Personal name | Koychev, Ivan |
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| Personal name | Millerd, Karla L. |
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| Personal name | Mackay, Clare |
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| Personal name | Jezzar, Peter |
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| Personal name | Smith, Stephen M. |
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| Personal name | Neubauer, Stefan |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://www.thelancet.com/action/showPdf?pii=S2589-5370%2820%2930427-2">https://www.thelancet.com/action/showPdf?pii=S2589-5370%2820%2930427-2</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | COVID 19 Resource |
| 999 ## - | |
| -- | 3787 |
| -- | 3787 |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| National Library of Medicine | DOH Central Library | DOH Central Library | Electronic Resource Section | 03/26/2021 | COVID-19-000162 | D0001C000162 | 03/26/2021 | 03/26/2021 | COVID 19 Resource |