Effects of garlic on total serum cholesterol : (Record no. 4004)

000 -LEADER
fixed length control field 02497nam a22001817a 4500
003 - CONTROL NUMBER IDENTIFIER
control field DOH
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20210413151436.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210413b ||||| |||| 00| 0 eng d
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Lim, Maricar G.
245 00 - TITLE STATEMENT
Title Effects of garlic on total serum cholesterol :
Remainder of title A meta-analysis /
Statement of responsibility, etc. Maricar G. Lim
520 3# - SUMMARY, ETC.
Summary, etc. Objectives: To investigate the effect of garlic on total cholesterol levels by conducting a meta-analysis of randomized, double-blinded, placebo-controlled trials.<br/><br/>Search strategy: Systematic literature searches were conducted on the MEDL1NE, OVID, the Cochrane Library, AMED and CINAHL databases and assessment of the bibliographies of published studies and reviews was done.<br/><br/>Selection criteria: Trials were selected if they were randomized and placebo-controlled and provide enough data to statistical pooling. Five of 25 studies were selected for the meta-analysis.<br/><br/>Data collection and Analysis: Details of study design, patient characteristics, intervention, duration of therapy and cholesterol measurements were extracted by one author. Analysis was done with the calculation of the weighted mean difference and chi square test using standard meta-analysis software (RevMan 4.2.3).<br/><br/>Mean results: In the five trials included in the meta-analysis, garlic reduced total cholesterol level from baseline significantly more than placebo; the weighted mean difference was -0.14 mmol/L (CI, 0.20 to -0.08). Heterogeneity was noted in our analysis therefore a separate analysis of studies using garlic tablets was done and revealed greater reduction of total serum cholesterol; weighted mean difference of-0.48 (95 percent CI, -0.61 to -0.35). Another analysis was done for trials with hypercholesterolemic subjects and showed significant total cholesterol improvement; weighted mean difference of-0.39 (95 percent CI, -0.49 to -0.29).<br/><br/>Conclusions: The result of this meta-analysis submits that garlic is significantly superior to placebo in lowering total cholesterol levels. The reduction of cholesterol level is modest and comparable to dietary interventions. Except for body odor, there are no studies demonstrating detrimental effects of garlic consumption. Therefore, with its other cardiovascular and health benefits, garlic is a reasonable alternative to lipid lowering drugs.
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note The Filipino Family Physician, 2003 41 (4) pages 130-140
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Garlic
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cholesterol
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Meta-Analysis
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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-- 4004
Holdings
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 04/13/2021   J000457 D0001J000457 04/13/2021 04/13/2021 Journal Article