BCG therapy in asthma / (Record no. 4209)

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fixed length control field 03179nam a22002177a 4500
003 - CONTROL NUMBER IDENTIFIER
control field DOH
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20210423164744.0
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fixed length control field 210423b ||||| |||| 00| 0 eng d
245 00 - TITLE STATEMENT
Title BCG therapy in asthma /
Statement of responsibility, etc. Aristeo G. Eslava [and three others]
520 3# - SUMMARY, ETC.
Summary, etc. This is an open trial to assess the efficacy of BCG therapy in extrinsic asthma. There were 40 patients (M=12, F=28) with a mean age of 32 years. Some 80% had a history of allergy. A good 88% gave a family history of asthma and other allergic diseases.<br/><br/>On entry, the chest x-ray was essentially normal in 77%, with bronchitis in 10% and pneumonitis 7.5%. these abnormalities were treated prior to BCG therapy. BCG was administered if PPD was negative on entry and on monthly follow-up for 1 year, 30% for 1-2 years and 17% for 2-3 years. Mean BCG vaccination/year was 5.2. Patients who completed 1 year or more of follow-up and without active PTB on chest x-ray were included in the study.<br/><br/>Mean asthma attack/year was significantly reduced from 18.2 was significantly reduced from 18.2 ± 10.0 to 6.1 ± 4.4 pre and post-BCG therapy respectively. Likewise, mean E.R. consult/year was significantly reduced from 9.6 ± 6.9 to 1.2 ± 2.0. Based on severity of asthma, there was sign ificant improvement from entry assessment: severe-17.5%, moderate-67.5% mild-15% to post-BCG assessment: severe-0%, moderate-10.5%, mild-82.5% and asymptomatic-7.5%. Peak flow rate measured by Wright's flow meter registered insignificant increase. Individually, the result was variable: 40% improved, 35% deteriorated while 25% showed no change.<br/><br/>The rationale for BCG therapy's salutary effects on asthma is conjectural. We propose the immune system is re-structured from a state of high IgE production and sensitivity to a state of "normal" IgE production that is less responsive to allergens. This we believe is achieved thru BCG's enhancing effect on suppressor T-cells which in turn influence the B cells to produce a different antibody, probably IgG. The final outcome is the production of less IgE antibodies which are also less responsive to allergens.<br/><br/>this being an open trial, the encouraging results of the study may be apparent. future controlled randomized trials may shed light on the validity and efficacy of this inexpensive and locally available modality treatment.<br/><br/>There is prevailing thought that the treatment of asthma is not only challenging but frustrating as well. Since it is triggered by variety of factors, some acting independently of each other, patient and doctor alike have labelled the disease incurable for want of wonder drug that can cure it regardless of cause or causes.<br/><br/>It is the purpose of this paper to lift the umbra of despair and focus attention on simple, cheap and readily available mode of treatment- BCG immunotherapy.
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note <br/>The Filipino Family Physician, 1985 23 ( 2) pages 1-7
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BCG Vaccine
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Asthma
General subdivision Therapy
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Bacillus Calmette Guerin Vaccine
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Eslava , Aristeo G.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Biso, Nicanor B.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Aseron, Cristina R.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Villasor, Roy P.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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-- 4209
-- 4209
Holdings
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 04/23/2021   J000542 D0001J000542 04/23/2021 04/23/2021 Journal Article