Comparative study of sublingual clonidine versus captopril in the emergency department management of hypertensive urgencies : (Record no. 4663)

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control field 20210514165218.0
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245 00 - TITLE STATEMENT
Title Comparative study of sublingual clonidine versus captopril in the emergency department management of hypertensive urgencies :
Remainder of title A prospective single blind study /
Statement of responsibility, etc. Marc Lamberto C. Reyes [and two others]
520 3# - SUMMARY, ETC.
Summary, etc. Hypertension remains a common but treatable problem worldwide. It is an important modifiable risk factor that may pose a threat to one's physical well-being and lifestyle, as well as it cause mortality if left unmanaged. In this study, a comparison is made between the efficacy of sublingual Captopril and sublinaual Clonidine in the management of hypertensive urgencies.<br/><br/>MATERIALS AND METHODS: Study population was taken from numerous hypertensive patients being seen in the Emergency Department of Makati Medical Center from January 1,2000 to April 1,2001.<br/><br/>INCLUSION CRITERIA: Requires each patient to be a known hypertensive maintained on a variety of medications, between the age of 35 to 65 years, and diagnosed to have urgent hypertension. Hypertensive urgency is defined herewith as an initial diastolic blood pressure (DBF) of 120mmHg or greater, and without signs of end organ dama.<br/><br/>PROCEDURES AND INTERVENTION: Subjects were assigned to Group A-Captopril or Group B-Clonidine via simple random sampling. Group A (60) received Captopril, supplied as 25 mg tablets sublingually, given hourly until target BP is reached or with a maximum of four doses. Group B (68) received Clonidine as 0.075 mg tablets sublingually, given hourly until target BP is reached or up to a maximum of four doses. After the initial dose of medications was administered, supine blood pressure and pulse rate were recorded every 10 minutes for the first two hours, then every 15 minutes for the remaining two hours, or until the target BP is reached. The target BP readings <=140/90 rnm Hg. At each interval, a clinical survey is performed to record symptoms and signs of possible adverse drug reactions.<br/><br/>DATA AND RESULTS: One hundred and twenty-eight subjects (128) were included in the study, sixty (60) for the Group A-Captopril group and sixty-eight (68) for the Group B- Clonidine group. Fifty eight percent (35/60) of the patients who received Captropil achieved the goal blood pressure of 140/90 within 120 minutes. By 240 minutes, 83 percent (50/60) of them reached this goal. Of the 60 patients in this group, nine of them (15 percent) failed to respond to the treatment. (For the Clonidine group, 71 percent (48/68) of the patients who received clonidine achieved the goal blood pressure of 140/90 within 120 minutes. By 240 minutes, 93 percent (63/68) of them reached this goal. Of the 68 patients in this group, five (7 percent) failed to respond to the treatment).<br/><br/>CONCLUSION: Results and statistical analyses of the study present to us showed that clonidine has a relatively faster onset of action and longer duration of action compared to captopril. It has safely and effectively lowered the systolic and diastolic pressures of the patients in the study at a rate and extent comparable with that of Captopril. Both drugs, however, are associated with systemic side effects, however, clonidine showed more side effects.
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note <br/>Makati Medical Center Proceedings, 2004 (18) pages 5-9
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Clonidine
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Captopril
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hypertension
General subdivision drug therapy
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Reyes, Marc Lamberto C.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sinon, Johnny B.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Singson, Hector C.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
999 ## -
-- 4663
-- 4663
Holdings
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 05/14/2021   J000634 D0001J000634 05/14/2021 05/14/2021 Journal Article