Is there a role for antibiotic prophylaxis in clean elective surgical procedures? : (Record no. 4668)

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Title Is there a role for antibiotic prophylaxis in clean elective surgical procedures? :
Remainder of title A randomized, controlled, double-blind study /
Statement of responsibility, etc. Leoderick V. Tubera [and three others]
520 3# - SUMMARY, ETC.
Summary, etc. OBJECTIVE: To determine whether antibiotic prophylaxis was necessary in preventing post - operative infectious complications in selected clean elective surgical procedures.<br/><br/>METHODOLOGY: Subjects were recruited from charity patients who underwent elective clean surgical procedures (thyroidectomy, herniorraphy with or without mesh insertion and vein stripping) at Makati Medical Center from 1 March 2003 to 1 November 2003. Excluded from the study were patients who were below 18 or above 75 years of age, malnourished, with known co- morbid conditions and on chronic steroid and cytotoxic therapy. Study participants randomly assigned to receive antibiotic prophylaxis were given intravenous preparation of first generation cephalosporin an hour prior to the surgical procedure. All subjects were then evaluated for clinical evidences of surgical site infection, such as fever, pain, swelling, warmth, erythema, loss of function, dehiscence, discharge and abscess formation, during the operation and on the 2nd, 3rd and 7th post-operative day. Data analysis used a 0.05 level of significance.<br/><br/>RESULTS: Fifty-five patients were included in the study. Antibiotic prophylaxis was given to 49.1 percent (27 subjects) of the study participants. On the other hand, prophylaxis was not administered to 50.1 percent (28 subjects). Patients with or without antibiotic prophylaxis remained afebrile and had gradual relief of pain during subsequent follow-up visits. There were also no accompanying signs of surgical wound infection observed for both study groups. Hence, no incidence of surgical site infection was seen within seven days after the clean elective surgical procedure.<br/><br/>CONCLUSION: Provided that proper asepsis and surgical techniques are strictly observed, absence of antibiotic prophylaxis for clean elective surgical procedures can be employed. (Author)
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Linking entry complexity note <br/>Makati Medical Center Proceedings, 2004 (18) pages 39-43
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Antibiotic Prophylaxis
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Tubera, Leoderick V.
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Personal name Pastores, John Vincent G.
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Personal name Padlan, Michael C.
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Personal name Marte, Jake J.
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Koha item type Journal Article
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Holdings
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 05/15/2021   J000639 D0001J000639 05/15/2021 05/15/2021 Journal Article