The effect of lidocaine and ropivacaine on the corneal endothelium in vitro / (Record no. 4671)

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fixed length control field 02134nam a22002057a 4500
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control field DOH
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control field 20210515130317.0
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fixed length control field 210515b ||||| |||| 00| 0 eng d
245 04 - TITLE STATEMENT
Title The effect of lidocaine and ropivacaine on the corneal endothelium in vitro /
Statement of responsibility, etc. Santiago A. Sibayan, Victor B. Lopez, Don Martin S. Ramos
520 3# - SUMMARY, ETC.
Summary, etc. Objective: The intracameral anesthesia is being used increasingly. These agents however may have toxic effects on the corneal endothelium. The purpose of the study is to determine whether the addition of preservative-free ropivacaine 0.2 percent, preservative-free ropivacaine 0.75 percent or preservative-free lidocaine 1 percent eyebank cornea preservative, Optisol, affects the endothelial cell count, hexagonality and pachymetry of human corneas.<br/><br/>Materials/Methodology: Human eyebank corneas were immersed in one of four solutions (Scorneas per group) namely control group (pure Optisol) or one of the three test group [1:1 mixture of Optisol plus preservative-free anesthetic (lidocaine 1 percent, ropivacaine 0.2 percent or ropivacaine 0.75 percent 0)]. Endothelial cell count, hexagonality and pachymetry were determined at baseline, 15, 30,45 and 60 minutes following exposure to these solutions. These values were then compared within and between groups using student's t test and one way ANOVA respectively. A p value of < 0.05 was considered statistically significant.<br/><br/>Results: Lidocaine 1 percent and ropivacaine 0.2 percent showed comparable toxic effects on the corneal endothelium. Ropivacaine 0.7.5 percent showed significantly more toxic effects than the other agents.<br/><br/>Conclusion: Compared to Lidocaine 1 percent, Ropivacaine 0.2 percent is equal to its toxicity profile on in its effect on the corneal endothelial cell count, hexagonality and pachymetry. (Author)
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note <br/><br/>Makati Medical Center Proceedings, 2004 (18) pages 53-56
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Lidocaine
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Ropivacaine
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Endothelium, Corneal
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sibayan, Santiago A.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lopez, Victor B.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Ramos, Don Martin S.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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-- 4671
Holdings
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 05/15/2021   J000642 D0001J000642 05/15/2021 05/15/2021 Journal Article