A randomized, blinded, placebo-controlled, pilot study on the effect of lyophilized bacterial extract on the hematopoietic recovery in immunosuppressed mice / (Record no. 4740)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02027nam a22002297a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DOH |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20210519140012.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210519b ||||| |||| 00| 0 eng d |
| 245 02 - TITLE STATEMENT | |
| Title | A randomized, blinded, placebo-controlled, pilot study on the effect of lyophilized bacterial extract on the hematopoietic recovery in immunosuppressed mice / |
| Statement of responsibility, etc. | Joey D. Borromeo [and two others] |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Chemotherapy, a mode of treatment for cancer patients renders depression of hematopoietic cells thus patients become more immunocompromised. When hematopoietic depression is severe, the use of colony-stimulating factors are advocated. However, due to their high cost, only few patients in our country benefit from its effect. Recent studies are centered in enhancing the patients own immune system to generate a response using immunomodulators/immunostimulators. A lyohilized bacterial extract (Broncho-Vaxom; BV) is an immunomodulating agent that is used in the treatment and prevention of recurrent respiratory tract infections. Its other uses had been explored using animal subjects. Recent studies on this drug is its readioprotective effect on irradiated mice. This randomized, blinded, placebo controlled study was conducted to evaluate the role of Broncho-Vaxom in the hematopoietic recovery of immunosuppressed mice. Immunosuppression was done by administering cyclophosphamide. Complete blood count and bone marrow aspirate were obtained to compare effect of BV from placebo treated mice. Results showed that BV does not have statistically significant effect on the acceleration of hematopoietic recovery in immunosuppressed mice. |
| 580 ## - LINKING ENTRY COMPLEXITY NOTE | |
| Linking entry complexity note | <br/>Makati Medical Center Proceedings, 1999 (13) pages 89-96 |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunoglobulins |
| General subdivision | administration and dosage |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Hematopoiesis |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Chemotherapy |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunosuppression |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Borromeo, Joey D. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lecciones, Julius A. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Victorio, Ma. Cristina C. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 999 ## - | |
| -- | 4740 |
| -- | 4740 |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| National Library of Medicine | DOH Central Library | DOH Central Library | Electronic Resource Section | 05/19/2021 | J000663 | D0001J000663 | 05/19/2021 | 05/19/2021 | Journal Article |