Paroxysmal nocturnal hemoglobinuria in a-17 year old (a case report) / Marie Emmeline B. Yu

By: Subject(s): Abstract: A rare disease merits general attention if it is associated with extraordinary clinical manifestations, unusual laboratory findings, or an instructive molecular defect. Paroxysmal nocturnal hemoglobinuria has all three. Its clinical hallmark, tea-colored urine in arising from sleep, is graphic testimony to intravascular hemolysis during the night. Even more peculiar is the hemolysis that occurs after blood from a patient with PNH is mixed with acidified serum or ordinary table sugar. The molecular abnormality in PNH not only inform us about this unusual disease but also points to a genetic lesion of widespread interest.
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Journal Article DOH Central Library Electronic Resource Section J000255 (Browse shelf) Available D0001J000255

A rare disease merits general attention if it is associated with extraordinary clinical manifestations, unusual laboratory findings, or an instructive molecular defect. Paroxysmal nocturnal hemoglobinuria has all three. Its clinical hallmark, tea-colored urine in arising from sleep, is graphic testimony to intravascular hemolysis during the night. Even more peculiar is the hemolysis that occurs after blood from a patient with PNH is mixed with acidified serum or ordinary table sugar. The molecular abnormality in PNH not only inform us about this unusual disease but also points to a genetic lesion of widespread interest.

Cebu Doctors' Proceedings, 1995 11 (2) pages 73-77

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