02423nam a22002537a 4500 D0001C000046 DOH 20201120134444.0 201120b ||||| |||| 00| 0 eng d The novel coronavirus Disease-2019 (COVID-19) : mechanism of action, detection and recent therapeutic strategies / Elahe Seyed Hosseini [and five others] Novel coronavirus SARS-CoV-2, designated as COVID-19 by the World Health Organization (WHO) on the February 11, 2020, is one of the highly pathogenic β‐coronaviruses which infects human. Early diagnosis of COVID-19 is the most critical step to treat infection. The diagnostic tools are generally molecular methods, serology and viral culture. Recently CRISPR-based method has been investigated to diagnose and treat coronavirus infection. The emergence of 2019-nCoV during the influenza season, has led to the extensive use of antibiotics and neuraminidase enzyme inhibitors, taken orally and intravenously. Currently, antiviral inhibitors of SARS and MERS spike proteins, neuraminidase inhibitors, anti-inflammatory drugs and EK1 peptide are the available therapeutic options for SARS-CoV-2 infected individuals. In addition, Chloroquine, which was previously used for malarial and autoimmune disease, has shown efficacy in the 2019-nCoV infection treatment. In severe hypoxaemia, a combination of antibiotics, α-interferon, lopinavir and mechanical ventilation can effectively mitigate the symptoms. Comprehensive knowledge on the innate and adaptive immune responses, will make it possible to propose potent antiviral drugs with their effective therapeutic measures for the prevention of viral infection. This therapeutic strategy will help patients worldwide to protect themselves against severe and fatal viral infections, that potentially can evolve and develop drug resistance, and to reduce mortality rates. In: Virology, 2020 vol. 551, pages: 1-9 Coronavirus Severe Acute Respiratory Syndrome therapy Immune response Hosseini, Elahe Seyed PhD Kashani, Narjes Riahi Nikzad, Hossein PhD Azadbakht, Javid PhD Bafrani, Hassan Hassani PhD Kashani, Hamed Haddad PhD https://www.sciencedirect.com/science/article/pii/S0042682220301720 CV 1780 1780 0 0 0 0 DOHCL DOHCL ElectronicRes 2020-11-20 0 COVID-19-000046 D0001C000046 2020-11-20 00:00:00 2020-11-20 CV