04714nam a22008777a 4500 D0001C000053 DOH 20201120160342.0 201120b ||||| |||| 00| 0 eng d Computational strategies to combat COVID-19 : useful tools to accelerate SARS-CoV-2 and coronavirus research / Franziska Hufsky [and fifty four others] SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. However, bioinformatics tools designed explicitly for SARS-CoV-2 have only recently been developed as a rapid reaction to the need for fast detection, understanding and treatment of COVID-19. To control the ongoing COVID-19 pandemic, it is of utmost importance to get insight into the evolution and pathogenesis of the virus. In this review, we cover bioinformatics workflows and tools for the routine detection of SARS-CoV-2 infection, the reliable analysis of sequencing data, the tracking of the COVID-19 pandemic and evaluation of containment measures, the study of coronavirus evolution, the discovery of potential drug targets and development of therapeutic strategies. For each tool, we briefly describe its use case and how it advances research specifically for SARS-CoV-2. All tools are free to use and available online, either through web applications or public code repositories. In: Briefings in Bioinformatics, bbaa232, https://doi.org/10.1093/bib/bbaa232 Coronavirus Computational Biology SARS-CoV-2 Bioinformatics Computational Molecular Biology Hufsky, Franziska Lamkiewicz, Kevin Almeida, Alexandre Aouacheria, Abdel Arighi, Cecilia Bateman, Alex Baumbach, Jan Beerenwinkel, Niko Brandt, Christian Cacciabue, Marco Chuguransky, Sara Drechsel, Oliver Finn, Robert D. Fritz, Adrian Fuchs, Stephan Hattab, Georges Hauschild, Anne-Christin Heider, Dominik Hoffmann, Marie Hölzer, Martin Hoops, Stefan Kaderali, Lars Kalvari, Ioanna Kleist, Max von Kmiecinski, Renó Kühnert, Denise Lasso, Gorka Libin, Pieter List, Markus Löchel, Hannah F. Martin, Maria J. Martin, Roman Matschinske, Julian McHardy, Alice C. Mendes, Pedro Mistry, Jaina Navratil, Vincent Nawrocki, Eric P. O’Toole, Áine Niamh Ontiveros-Palacios, Nancy Petrov, Anton I. Rangel-Pineros, Guillermo Redaschi, Nicole Reimering, Susanne Reinert, Knut Reyes, Alejandro Richardson, Lorna Robertson, David L. Sadegh, Sepideh Singer, Joshua B. Theys, Kristof Upton, Chris Welzel, Marius Williams, Lowri Williams, Lowri Marz, Manja https://watermark.silverchair.com/bbaa232.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArQwggKwBgkqhkiG9w0BBwagggKhMIICnQIBADCCApYGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMpq7lgBV3HN5z4lyOAgEQgIICZ1K4pDpMDVpIcRPijG9gfLDCQ_ONvJrqOVE53KHeG97-bhlDZiSaCHiBc9at-4xcWNpHSC2F88m8h6j1DCxkbS04M2mApfx7CVzt09rTaf3bAVlbhBI7cnTlbpQ2OaZZavOrEnJWpjLeN7FhuC80Xk5x7xJwsfA_xtT3fc33Hb7Ddu3SycwMHsyrdwnbRZ05OdXeTtCWbGrpB5N_Jc4QCCm8-seoVkhbsBMGgpcSEHA0RqtQlxaFE547uZTQM1F_6gnjfrJkaOJ6Bm7mTyV9cVOkyC6rFLxwZdbDKYSKVDfgPu_PLVdWr6T8J4VKQ_R9TsUctbQoFMsyG2aJWAHlqgoyQjyQliZdzqveVMzZEh_L1C2sA743zLJ2U5IFYZQ8eeuml9JotzAfpngDWTz-v-Vc-AllCVgDktLaU04yHH7dDxcAbhdewDjeNT3g-408KEnU2dTFqSgyimhbz5vzQR1tAQgJ003qv-3wKYIdcSSoq6w2zLcMATWqNl43Hp9V_pjtJZ6a69BqhT1RgGSyvDTIWYLFVHarflk-mZDW93cHHiJm0RRuuvXaSepFPQQWt8CgF1HAicKktseBzgwg0dt6mfBffoBs6A-IKcTa5RvI-BdSz7UUe67QT55tyaSqzjXxiYyYUNVgMkGaoJ2X1QCiN-2qMTMVcE-WAcE7QvocbQaQF5Y6GY_mWhpLvGP2m7mjG0WyGdQIx4uPv3UpEcYDEYGQWo-q7lLJiIV_GZgli_UrJh4DypFi1QYz5cnVEDVDQ8H3InooMKEGXte8uHofTwkCOQDxTxq-xXbkaHQY_VLrwCnJgw CV 1786 1786 0 0 0 0 DOHCL DOHCL ElectronicRes 2020-11-20 0 COVID-19-000053 D0001C000053 2020-11-20 00:00:00 2020-11-20 CV