02201nam a22002297a 4500001001300000003000400013005001700017008004100034245010900075520120700184580010101391650004201492650003801534650004201572650006401614650007701678650006401755700002901819700002201848700002301870856007801893D0001C000058DOH20201121152257.0201121b           ||||| |||| 00| 0 eng d00aPathogenesis of Middle East respiratory syndrome coronavirus /cJudith MA van den Brand [and two others]3 aHuman coronaviruses (CoVs) mostly cause a common cold that is mild and self-limiting. Zoonotic transmission of CoVs such as the recently identified Middle East respiratory syndrome (MERS)-CoV and severe acute respiratory syndrome (SARS)-CoV, on the other hand, may be associated with severe lower respiratory tract infection. This article reviews the clinical and pathological data available on MERS and compares it to SARS. Most importantly, chest radiographs and imaging results of patients with MERS show features that resemble the findings of organizing pneumonia, different from the lesions in SARS patients, which show fibrocellular intra-alveolar organization with a bronchiolitis obliterans organizing pneumonia-like pattern. These findings are in line with differences in the induction of cytopathological changes, induction of host gene responses and sensitivity to the antiviral effect of interferons in vitro when comparing both MERS-CoV and SARS-CoV. The challenge will be to translate these findings into an integrated picture of MERS pathogenesis in humans and to develop intervention strategies that will eventually allow the effective control of this newly emerging infectious disease.  aIn: J Pathol. 2015 Jan; 235 (2): 175–184.
Published online 2014 Dec 11. doi: 10.1002/path.4458 2a Coronavirus Infectionsxdrug therapy 2aCoronavirus Infectionsxvirology* 2a Coronavirus Infectionsxtransmission 2a Middle East Respiratory Syndrome Coronavirusxdrug effects 2aMiddle East Respiratory Syndrome Coronavirusxisolation and purification 2aMiddle East Respiratory Syndrome Coronavirusxpathogenicity1 aBrand, Judith MA van den1 aSmits,  Saskia L 1 aHaagmans,  Bart L   uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167882/pdf/PATH-235-175.pdf