02997nam a22003857a 4500 D0001C000063 DOH 20201123114606.0 201123b ||||| |||| 00| 0 eng d A case study evaluating the risk of infection from Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) in a hospital setting through bioaerosols / Umesh Adhikari [and eleven others] Middle Eastern respiratory syndrome, an emerging viral infection with a global case fatality rate of 35.5%, caused major outbreaks first in 2012 and 2015, though new cases are continuously reported around the world. Transmission is believed to mainly occur in healthcare settings through aerosolized particles. This study uses Quantitative Microbial Risk Assessment to develop a generalizable model that can assist with interpreting reported outbreak data or predict risk of infection with or without the recommended strategies. The exposure scenario includes a single index patient emitting virus-containing aerosols into the air by coughing, leading to short- and long-range airborne exposures for other patients in the same room, nurses, healthcare workers, and family visitors. Aerosol transport modeling was coupled with Monte Carlo simulation to evaluate the risk of MERS illness for the exposed population. Results from a typical scenario show the daily mean risk of infection to be the highest for the nurses and healthcare workers (8.49 × 10-4 and 7.91 × 10-4 , respectively), and the lowest for family visitors and patients staying in the same room (3.12 × 10-4 and 1.29 × 10-4 , respectively). Sensitivity analysis indicates that more than 90% of the uncertainty in the risk characterization is due to the viral concentration in saliva. Assessment of risk interventions showed that respiratory masks were found to have a greater effect in reducing the risks for all the groups evaluated (>90% risk reduction), while increasing the air exchange was effective for the other patients in the same room only (up to 58% risk reduction). In: Risk Analysis 2019 vol. 39 (12) pages: 2608-2624. doi: 10.1111/risa.13389. Epub 2019 Sep 16. Aerosols Air Microbiology Coronavirus Infections epidemiology Coronavirus Infections transmission Cross Infection prevention and control Masks Middle East Respiratory Syndrome Coronavirus Risk Management Adhikari, Umesh Chabrelie, Alexandre Weir, Mark Boehnke, Kevin McKenzie, Erica Ikner, Luisa Wang, Meng Wang, Qing Young, Kyana Haas, Charles N Rose, Joan Mitchell, Jade https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169172/pdf/RISA-39-2608.pdf CV 1796 1796 0 0 0 0 DOHCL DOHCL ElectronicRes 2020-11-23 0 COVID-19-000063 D0001C000063 2020-11-23 00:00:00 2020-11-23 CV