01548nam a22001937a 4500 D0001J000159 DOH 20210312143258.0 210312b ||||| |||| 00| 0 eng d Montoya, Jaime C. Diagnosis of tuberculous meningitis using enzyme-linked immunosorbent assay utilizing a 30,000-dalton native antigen of mycobacterium tuberculosis / Jaime C. Montoya An enzyme-linked immunosorbent assay (ELISA) was estimated for the detection of lgG antibody in human cerebrospinal fluid (CSF) from patients with tuberculous meningitis to the 30,000-Da native antigen of Mycobacterium tuberculosis. The test was done on patients with bacteriologically confirmed and autopsy-proven tuberculous meningitis (8 cases), clinically presumptive cases of tuberculous neurologic disease (88 cases) and normal patients with neurologic disease (10 cases). The test was positive in 7 of the 8 cases of bacteriologically confirmed tuberculous meningitis (87.5%). ELISA was also positive in 67 of 100 cases of clinically presumptive tuberculous meningitis (67.00%). Overall sensitivity was found to be 68.51%. Specificity of ELISA was found to be 97.95% (96/98). The results show the potential use of ELISA as a rapid diagnosis test for tuberculous meningitis . Acta Medica Philippina, 2000 36 ( 1&2 ) pages 22-26 Tuberculosis, Meningeal diagnosis Enzyme-Linked Immunosorbent Assay Mycobacterium tuberculosis Antigens JA 3473 3473 0 0 nlm 0 0 DOHCL DOHCL ElectronicRes 2021-03-12 0 J000159 D0001J000159 2021-03-12 00:00:00 2021-03-12 JA