01081nam a22001457a 4500001001300000003000400013005001700017008004100034100002700075245009700102520063200199580005600831650003100887650001700918D0001J000255DOH20210320151642.0210320b           ||||| |||| 00| 0 eng d1 aYu, Marie Emmeline B. 00aParoxysmal nocturnal hemoglobinuria in a-17 year old (a case report) /cMarie Emmeline B. Yu3 aA rare disease merits general attention if it is associated with extraordinary clinical manifestations, unusual laboratory findings, or an instructive molecular defect. Paroxysmal nocturnal hemoglobinuria has all three. Its clinical hallmark, tea-colored urine in arising from sleep, is graphic testimony to intravascular hemolysis during the night. Even more peculiar is the hemolysis that occurs after blood from a patient with PNH is mixed with acidified serum or ordinary table sugar. The molecular abnormality in PNH not only inform us about this unusual disease but also points to a genetic lesion of widespread interest.  aCebu Doctors' Proceedings, 1995 11 (2) pages  73-77 2aHemoglobinuria, Paroxysmal 2aCase Reports