Yu, Marie Emmeline B. creator text monographic eng

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A rare disease merits general attention if it is associated with extraordinary clinical manifestations, unusual laboratory findings, or an instructive molecular defect. Paroxysmal nocturnal hemoglobinuria has all three. Its clinical hallmark, tea-colored urine in arising from sleep, is graphic testimony to intravascular hemolysis during the night. Even more peculiar is the hemolysis that occurs after blood from a patient with PNH is mixed with acidified serum or ordinary table sugar. The molecular abnormality in PNH not only inform us about this unusual disease but also points to a genetic lesion of widespread interest. Marie Emmeline B. Yu Cebu Doctors' Proceedings, 1995 11 (2) pages 73-77 Hemoglobinuria, Paroxysmal Case Reports 210320 20210320151642.0 D0001J000255