04233nam a22008057a 4500 D0001C000162 DOH 20210326105912.0 210326b ||||| |||| 00| 0 eng d Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge / Betty Raman [forty nine others] Background: The medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality of life and mental health are poorly understood. Methods: Fifty-eight COVID-19 patients post-hospital discharge and 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver and kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary exercise test (CPET), quality of life, cognitive and mental health assessments. Findings: At 2-3 months from disease-onset, 64% of patients experienced breathlessness and 55% reported fatigue. On MRI, abnormalities were seen in lungs (60%), heart (26%), liver (10%) and kidneys (29%). Patients exhibited changes in the thalamus, posterior thalamic radiations and sagittal stratum on brain MRI and demonstrated impaired cognitive performance, specifically in the executive and visuospatial domains. Exercise tolerance (maximal oxygen consumption and ventilatory efficiency on CPET) and six-minute walk distance were significantly reduced. The extent of extra-pulmonary MRI abnormalities and exercise intolerance correlated with serum markers of inflammation and acute illness severity. Patients had a higher burden of self-reported symptoms of depression and experienced significant impairment in all domains of quality of life compared to controls (p<0.0001 to 0.044). Interpretation: A significant proportion of patients discharged from hospital reported symptoms of breathlessness, fatigue, depression and had limited exercise capacity. Persistent lung and extra-pulmonary organ MRI findings are common in patients and linked to inflammation and severity of acute illness. EClinicalMedicine, 2021 Jan 7;31:100683. doi: 10.1016/j.eclinm.2020.100683 COVID-19 Coronavirus Magnetic Resonance Imaging Mental Health Survivors Multiorgan Effects Raman, Betty Cassar, Mark Philip Tunnicliffe, Elizabeth M. Filippini, Nicola Griffanti, Ludovica Alfaro-Almagro, Fidel Okell, Thomas Sheerin, Fintan Xie, Cheng Mahmod, Masliza Moze, Ferenc E. Lewandowski, Adam J. Ohuma, Eric O. Holdsworth, David Lamlum, Hanan Woodman, Myles J. Krasopoulos, Catherine Mills, Rebecca McConnell, Flora A. Kennedy Wang, Chaoyue Arthofer, Christoph Lange, Frederik J. Andersson, Jesper Jenkinson, Mark Antoniades, Charalambos Channon, Keith M. Shanmuganathan, Mayooran Ferreira, Vanessa M. Piechnik, Stefan K. Klenerman, Paul Brightling, Christopher Talbot, Nick P. Petousik, Nayia Rahman, Najib M. Hom, Ling-Pei Saunders, Kate Geddes, John R. Harrison, Paul J. Pattinsono, Kyle Rowlando, Matthew J. Angus, Brian J. Gleeson, Fergus Pavlides, Michael Koychev, Ivan Millerd, Karla L. Mackay, Clare Jezzar, Peter Smith, Stephen M. Neubauer, Stefan https://www.thelancet.com/action/showPdf?pii=S2589-5370%2820%2930427-2 CV 3787 3787 0 0 nlm 0 0 DOHCL DOHCL ElectronicRes 2021-03-26 0 COVID-19-000162 D0001C000162 2021-03-26 00:00:00 2021-03-26 CV