The efficacy of different concentrations of Morinda citrifolia (Noni) cream preparations in the treatment of staphylococcal full-thickness burn wound infection in mice /
Arnel S. Nuguid [and two others]
Design: Prospective Descriptive Analytical Animal Experiment. Objective: To compare the efficacy of the 2 percent, 4 percent and 10 percent Morinda citrifolia (Noni) extract cream against commercially-prepared antibacterials in the treatment of Staphylococcus aureus infection in full-thickness burn wounds among mice. Methodology: Fifty-four pathogen free mice were divided randomly into six groups. A full-thickness burn wound was created over the backs of each mice and swabbed with Staphylococcus aureus. One group served as control, and the rest were treated with 2 percent, 4 percent and 10 percent Noni cream preparations, mupirocin and silver sulfadiazine for seven days. Every day one mouse from each group was sacrificed and their skins were sent for histopathologic studies. Results: Full thickness burn wounds of mice infected with Staphylococcus aureus treated with 10 percent noni cream preparation retained their full thickness character, were cleared of S. aureus infection and showed histologic absence of wound infection as early as the 3rd day of treatment. These were comparable with those obtained from the infected burn wounds of mice treated mupirocin cream and silver sulfadiazine cream. However, mice that were treated with 2 percent and 4 percent Noni cream preparations, although proven to be effective as an antibacterial agent as evidenced by retention of the full thickness wound disappearance of S. aureus growth on the 7th day of treatment and control of inflammatory response histopathologically, had a slower onset of action as compared to their 10 percent counterparts. In contrast, the control group had evidences of uncontrolled S. aureus infection and histological specimens showed extension of necrosis to the muscular layer with persistence of infiltrating cells up to day seven of the experiment. Conclusion: This study has demostrated the efficacy of the 10 percent Morinda citrifolia (Noni) cream preparation in the treatment of Staphylococcus aureus infection in full thickness burn wounds in mice. (Author)
Objectives To compare the efficacy of the 2 percent, 4 percent and 10 percent Morinda citrifolia (noni) extract cream against commercially-prepared antibacterials in the treatment of Staphylococcus aureus infection in full thickness burn wounds among mice.
Makati Medical Center Proceedings, 2004 (18) pages 79-86