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| 005 | 20201029125852.0 | ||
| 008 | 201029b ||||| |||| 00| 0 eng d | ||
| 245 | 0 | 0 |
_aReconstruction of 60 years of chikungunya epidemiology in the Philippines demonstrates episodic and focal transmission / _cHenrik Salje [and seventeen others] |
| 520 | 3 | _aProper understanding of the long-term epidemiology of chikungunya has been hampered by poor surveillance. Outbreak years are unpredictable and cases often misdiagnosed. Here we analyzed age-specific data from 2 serological studies (from 1973 and 2012) in Cebu, Philippines, to reconstruct both the annual probability of infection and population-level immunity over a 60-year period (1952-2012). We also explored whether seroconversions during 2012-2013 were spatially clustered. Our models identified 4 discrete outbreaks separated by an average delay of 17 years. On average, 23% (95% confidence interval [CI], 16%-37%) of the susceptible population was infected per outbreak, with >50% of the entire population remaining susceptible at any point. Participants who seroconverted during 2012-2013 were clustered at distances of <230 m, suggesting focal transmission. Large-scale outbreaks of chikungunya did not result in sustained multiyear transmission. Nevertheless, we estimate that >350 000 infections were missed by surveillance systems. Serological studies could supplement surveillance to provide important insights on pathogen circulation. | |
| 580 | _aIn: The Journal of Infectious Diseases 2016 Vol. 213 (4) page 604-10. | ||
| 650 | 0 | 2 |
_aChikungunya Fever _xepidemiology |
| 650 | 0 | 2 |
_aChikungunya Fever _xhistory |
| 650 | 0 | 2 |
_aChikungunya Fever _xtransmission |
| 650 | 0 | 2 | _aDisease Transmission, Infectious |
| 653 | _aSerological Study | ||
| 700 | 1 | _aSalje, Henrik | |
| 700 | 1 | _aCauchemez, Simon | |
| 700 | 1 | _aAlera, Maria Theresa | |
| 700 | 1 | _aRodriguez-Barraquer, Isabel | |
| 700 | 1 | _aThaisomboonsuk, Butsaya | |
| 700 | 1 | _aSrikiatkhachorn, Anon | |
| 700 | 1 | _aLago, Catherine B. | |
| 700 | 1 | _aVilla, Daisy | |
| 700 | 1 | _aKlungthong, Chonticha | |
| 700 | 1 | _aTac-An, Ilya A. | |
| 700 | 1 | _aFernandez, Stefan | |
| 700 | 1 | _aVelasco, John Mark | |
| 700 | 1 | _aRoque, Vito G., Jr | |
| 700 | 1 | _aNisalak, Ananda | |
| 700 | 1 | _aMacareo, Louis R. | |
| 700 | 1 | _aLevy, Jens W. | |
| 700 | 1 | _aCummings, Derek | |
| 700 | 1 | _aYoon, In-Kyu | |
| 856 | _uhttps://watermark.silverchair.com/jiv470.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAqAwggKcBgkqhkiG9w0BBwagggKNMIICiQIBADCCAoIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMCFG-5xE2JVU14ufpAgEQgIICU2q0rPx0uLiM0Fs_yjAp7PAEuNAnQlOYVR9COgYE3fB6cYFNCfhOd53_JLIb-CcBZdVdkX4Fj-o1lC4IF6zNQQj9RJUwAz21SZ2RRH0LlF9TYXjRqWFi4JOBL6vAg72eTF7iielMENTImwR1Q6mOUZhhNIaauXJjs44Py4jkuT4hMfYRHQFTdsLcJHykwtXLi3mi1WHBDMP9ZusOpdJXrzYonJiwkPOlElkboc1pKNc4HPILrp6Uu5RBOSz68TiPd4ypvGw5TNVzd7wPSwpB0iHtQoelfNrj4ceH9ulh_AwgtFUi3oiNaCHQKc5dSRiyHRWeEZUpcxIZ8L473aEzbcLSfprc3EpsoSXOOOnzip-TcSQ4QGqCTd3LmMlaPBozXKl9VC3spVi8_yhPm1pn-liSkVfzLL7ox6X_JiXWpzAFAyAFQRVyiuU129S0-V15QeOEwxZ9cptt-safZaWlBIHaTmuo6BSPB6dD72V0JYwB9FCeaXFLaM-I3XPSB5_MI7U6T-oGxb1w4wEDhLvrYF0YttMgZM0dUsmTGK3FFuCMrA8rgFlHUPpjvsmnwuRxNwbTjHhP-53dKOPN5wbE44ylHRBkeN7LIOmI1M8QKyD797sw-EuHbKJeTeZfshswbXsVzJMXP_jGTYMUblcZuLmjMENybImkHR8lGFJpQa-LUL07S4EY_dQTXueXXvjYV-vaShh3l0qdu32AaIQZ--xieSXYHEVxx_ktQ1e8xX1cQcgAEtUa9vwAMiKB77F82k7T-OwphBsX2pHC1mez-KYB4SY | ||
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