000			02120nam a22002897a 4500
001			D0001C000068
003			DOH
005			20201123135418.0
008			201123b ||||| |||| 00| 0 eng d
245	0	0	_aEmerging lethal infectious bronchitis coronavirus variants with multiorgan tropism / _cYao-Tsun Li [and six others]
520			_aInfectious bronchitis virus (IBV) causes respiratory diseases in chickens and poses an economic threat to the poultry industry worldwide. Despite vaccine use, there have been field outbreaks of IBV in Taiwan. This study aimed to characterize the emerging IBV variants circulating in Taiwan. The analysis of the structural protein genes showed that these variants emerged through frequent recombination events among Taiwan strains, China strains, Japan strains and vaccine strains. Cross-neutralization tests revealed that two of the variants exhibited novel serotypes. Clinicopathological assessment showed that two of the variants caused high fatality rates of 67% and 20% in one-day-old SPF chicks, and all the variants possessed multiorgan tropisms, including trachea, proventriculus and urogenital tissues. Furthermore, the commercial live-attenuated Mass-type vaccine conferred poor protection against these variants. This study identified novel genotypes, serotypes and pathotypes of emerging IBV variants circulating in Taiwan. There is an urgent need for effective countermeasures against these variant strains.
580			_aIn: Transboundary Emerging Disease. 2020 Vol. 67 (2) pages:884-893. doi: 10.1111/tbed.13412. Epub 2019 Nov 20.
650		2	_aBronchitis _xvirology
650		2	_a Coronavirus Infections _xepidemiology
650		2	_aDisease Outbreaks _xveterinary
650		2	_aPoultry Diseases _xepidemiology
650		2	_aViral Tropism
700	1		_aLi, Yao‐Tsun
700	1		_aChen, Ting‐Chih
700	1		_aLin, Shu‐Yi
700	1		_aMase, Masaji
700	1		_aMurakami, Shin
700	1		_aHorimoto, Taisuke
700	1		_aChen, Hui‐Wen
856			_uhttps://onlinelibrary.wiley.com/doi/full/10.1111/tbed.13412
942			_cCV
999			_c1807 _d1807