000			01754nam a22002057a 4500
001			D0001J000318
003			DOH
005			20210324163102.0
008			210324b ||||| |||| 00| 0 eng d
245	0	0	_aA preliminary study on the oral acute toxicity of kintsay (Apium graviolens L.) in BFAD : ICR mice _b ICR mice / _cFlordeliza S. Aungon, Oscar G. Gutierrez
520	3		_aKintsay (Apium graviolens L.) is know to have some diuretic and hypotensive effects in man. A preliminary study on the oral toxicity of kintsay in BFAD: ICR mice was carried out. A pure extract was prepared and orally administered to four groups of mice of each sex at the dose levels of 160, 240, 320 and 400 mg/kg body weight. The treatment resulted in one mortality for each sex from the highest dose group. The female died in 1 hour and 25 minutes post-treatment after showing signs of decrease motor activity, ataxia, head-shaking, lethargy and abdominal breathing, while the male died after 8 days without exhibiting any toxic signs and loss in body weight. Upon necropsy, the male mouse have enlarged liver and spleen. The estimated median lethal dose of kintsay in mice was more than 400 mg/kg body weight. The findings of the preliminary study in mice gave indication that kintsay at large single dose may have delayed systemic effects with deleterious consequence other than the immediate lethal toxic effect. A definitive oral acute toxicity test of kintsay is recommended in the future.(Author)
580			_aBFAD Laboratory Information Bulletin, 1995 1 (1) pages 5-8
650		2	_aApium
650		2	_aToxicity Tests
653			_aApium graviolens L
653			_aKintsay
700	1		_aAungon, Flordeliza S.
700	1		_aGutierrez, Oscar G.
942			_cJA
999			_c3769 _d3769