000			03643nam a22002057a 4500
001			D0001J000634
003			DOH
005			20210514165218.0
008			210514b ||||| |||| 00| 0 eng d
245	0	0	_aComparative study of sublingual clonidine versus captopril in the emergency department management of hypertensive urgencies : _bA prospective single blind study / _cMarc Lamberto C. Reyes [and two others]
520	3		_aHypertension remains a common but treatable problem worldwide. It is an important modifiable risk factor that may pose a threat to one's physical well-being and lifestyle, as well as it cause mortality if left unmanaged. In this study, a comparison is made between the efficacy of sublingual Captopril and sublinaual Clonidine in the management of hypertensive urgencies. MATERIALS AND METHODS: Study population was taken from numerous hypertensive patients being seen in the Emergency Department of Makati Medical Center from January 1,2000 to April 1,2001. INCLUSION CRITERIA: Requires each patient to be a known hypertensive maintained on a variety of medications, between the age of 35 to 65 years, and diagnosed to have urgent hypertension. Hypertensive urgency is defined herewith as an initial diastolic blood pressure (DBF) of 120mmHg or greater, and without signs of end organ dama. PROCEDURES AND INTERVENTION: Subjects were assigned to Group A-Captopril or Group B-Clonidine via simple random sampling. Group A (60) received Captopril, supplied as 25 mg tablets sublingually, given hourly until target BP is reached or with a maximum of four doses. Group B (68) received Clonidine as 0.075 mg tablets sublingually, given hourly until target BP is reached or up to a maximum of four doses. After the initial dose of medications was administered, supine blood pressure and pulse rate were recorded every 10 minutes for the first two hours, then every 15 minutes for the remaining two hours, or until the target BP is reached. The target BP readings <=140/90 rnm Hg. At each interval, a clinical survey is performed to record symptoms and signs of possible adverse drug reactions. DATA AND RESULTS: One hundred and twenty-eight subjects (128) were included in the study, sixty (60) for the Group A-Captopril group and sixty-eight (68) for the Group B- Clonidine group. Fifty eight percent (35/60) of the patients who received Captropil achieved the goal blood pressure of 140/90 within 120 minutes. By 240 minutes, 83 percent (50/60) of them reached this goal. Of the 60 patients in this group, nine of them (15 percent) failed to respond to the treatment. (For the Clonidine group, 71 percent (48/68) of the patients who received clonidine achieved the goal blood pressure of 140/90 within 120 minutes. By 240 minutes, 93 percent (63/68) of them reached this goal. Of the 68 patients in this group, five (7 percent) failed to respond to the treatment). CONCLUSION: Results and statistical analyses of the study present to us showed that clonidine has a relatively faster onset of action and longer duration of action compared to captopril. It has safely and effectively lowered the systolic and diastolic pressures of the patients in the study at a rate and extent comparable with that of Captopril. Both drugs, however, are associated with systemic side effects, however, clonidine showed more side effects.
580			_a Makati Medical Center Proceedings, 2004 (18) pages 5-9
650		2	_aClonidine
650		2	_aCaptopril
650		2	_aHypertension _xdrug therapy
700	1		_aReyes, Marc Lamberto C.
700	1		_aSinon, Johnny B.
700	1		_aSingson, Hector C.
942			_cJA
999			_c4663 _d4663