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245	0	0	_aIs there a role for antibiotic prophylaxis in clean elective surgical procedures? : _bA randomized, controlled, double-blind study / _cLeoderick V. Tubera [and three others]
520	3		_aOBJECTIVE: To determine whether antibiotic prophylaxis was necessary in preventing post - operative infectious complications in selected clean elective surgical procedures. METHODOLOGY: Subjects were recruited from charity patients who underwent elective clean surgical procedures (thyroidectomy, herniorraphy with or without mesh insertion and vein stripping) at Makati Medical Center from 1 March 2003 to 1 November 2003. Excluded from the study were patients who were below 18 or above 75 years of age, malnourished, with known co- morbid conditions and on chronic steroid and cytotoxic therapy. Study participants randomly assigned to receive antibiotic prophylaxis were given intravenous preparation of first generation cephalosporin an hour prior to the surgical procedure. All subjects were then evaluated for clinical evidences of surgical site infection, such as fever, pain, swelling, warmth, erythema, loss of function, dehiscence, discharge and abscess formation, during the operation and on the 2nd, 3rd and 7th post-operative day. Data analysis used a 0.05 level of significance. RESULTS: Fifty-five patients were included in the study. Antibiotic prophylaxis was given to 49.1 percent (27 subjects) of the study participants. On the other hand, prophylaxis was not administered to 50.1 percent (28 subjects). Patients with or without antibiotic prophylaxis remained afebrile and had gradual relief of pain during subsequent follow-up visits. There were also no accompanying signs of surgical wound infection observed for both study groups. Hence, no incidence of surgical site infection was seen within seven days after the clean elective surgical procedure. CONCLUSION: Provided that proper asepsis and surgical techniques are strictly observed, absence of antibiotic prophylaxis for clean elective surgical procedures can be employed. (Author)
580			_a Makati Medical Center Proceedings, 2004 (18) pages 39-43
650		2	_aAntibiotic Prophylaxis
700	1		_aTubera, Leoderick V.
700	1		_aPastores, John Vincent G.
700	1		_aPadlan, Michael C.
700	1		_aMarte, Jake J.
942			_cJA
999			_c4668 _d4668