| 000 | 02658nmm a2200349 n 4500 | ||
|---|---|---|---|
| 999 |
_c763 _d763 |
||
| 003 | DOH | ||
| 005 | 20200806155505.0 | ||
| 008 | 200526p ph ||||||||z| 00| 0 eng d | ||
| 040 | _cDOH | ||
| 245 | 0 | 0 |
_aNutritional status and serum cytokine profiles in children, adolescents, and young adults with schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines / _cHannah M. Coutinho [ and eleven others] |
| 520 | 3 |
_aIn a cross-sectional study of 641 Schistosoma japonicum-infected individuals in Leyte, Philippines, who were 7-30 years old, we determined the grade of hepatic fibrosis (HF) by ultrasound and used anthropometric measurements and hemoglobin levels to assess nutritional status. Serum levels of interleukin (IL)-1, IL-6, and IL-10; tumor-necrosis factor (TNF)-alpha; soluble TNF- alpha receptor I; and C-reactive protein (CRP) were measured to examine the association between these markers of inflammation and HF grade. HF was present in 8.9% of the cohort; the majority of cases were mild (grade I), and severe (grade II or grade III) cases occurred only in male individuals. Compared with individuals without HF, those with severe HF--and, to a lesser degree, those with mild HF--had a significantly lower body-mass index (BMI) and BMI z-score, a higher prevalence of anemia, and a higher level of CRP and were more likely to produce IL-6; furthermore, those with severe HF had a significantly higher level of IL-1, compared with those either without HF or with mild HF. These findings suggest that even mild HF is associated with nutritional morbidity and underscore the importance of early recognition and treatment. In addition, our data are consistent with the hypothesis that, by systemically increasing the levels of the proinflammatory cytokines IL-1 and IL-6, HF causes undernutrition and anemia. _uhttps://pubmed.ncbi.nlm.nih.gov/15995969/ |
|
| 580 | _aIn: Journal of Infectious Diseases, 2005 vol. 192 (1) pages 528-536. | ||
| 650 | 2 |
_aChild _zPhilippines |
|
| 650 | 2 |
_a Cytokines _xblood |
|
| 650 | 2 |
_aHemoglobins _xmetabolism |
|
| 650 | 2 |
_a Liver Cirrhosis _ximmunology |
|
| 650 | 2 |
_aSchistosomiasis japonica _xcomplications |
|
| 700 | 1 | _aCoutinho , Hannah M. | |
| 700 | 1 | _aMcGarvey, Stephen T. | |
| 700 | 1 | _aAcosta, Luz P. | |
| 700 | 1 | _aManalo, Daria L. | |
| 700 | 1 | _aLangdon, Daria L. | |
| 700 | 1 | _a Leenstra, Tjalling | |
| 700 | 1 | _aKanzaria, Hemal K. | |
| 700 | 1 | _aSolomon, Julie | |
| 700 | 1 | _aWu, Haiwei | |
| 700 | 1 | _aOlveda, Remigio M | |
| 700 | 1 | _aKurtis, Jonathan D. | |
| 700 | 1 | _aFriedman, Jennifer F. | |
| 856 | _uhttps://academic.oup.com/jid/article/192/3/528/836616 | ||
| 942 | _cJA | ||