The effect of lidocaine and ropivacaine on the corneal endothelium in vitro / Santiago A. Sibayan, Victor B. Lopez, Don Martin S. Ramos
Subject(s): Abstract: Objective: The intracameral anesthesia is being used increasingly. These agents however may have toxic effects on the corneal endothelium. The purpose of the study is to determine whether the addition of preservative-free ropivacaine 0.2 percent, preservative-free ropivacaine 0.75 percent or preservative-free lidocaine 1 percent eyebank cornea preservative, Optisol, affects the endothelial cell count, hexagonality and pachymetry of human corneas. Materials/Methodology: Human eyebank corneas were immersed in one of four solutions (Scorneas per group) namely control group (pure Optisol) or one of the three test group [1:1 mixture of Optisol plus preservative-free anesthetic (lidocaine 1 percent, ropivacaine 0.2 percent or ropivacaine 0.75 percent 0)]. Endothelial cell count, hexagonality and pachymetry were determined at baseline, 15, 30,45 and 60 minutes following exposure to these solutions. These values were then compared within and between groups using student's t test and one way ANOVA respectively. A p value of < 0.05 was considered statistically significant. Results: Lidocaine 1 percent and ropivacaine 0.2 percent showed comparable toxic effects on the corneal endothelium. Ropivacaine 0.7.5 percent showed significantly more toxic effects than the other agents. Conclusion: Compared to Lidocaine 1 percent, Ropivacaine 0.2 percent is equal to its toxicity profile on in its effect on the corneal endothelial cell count, hexagonality and pachymetry. (Author)| Cover image | Item type | Current library | Home library | Collection | Shelving location | Call number | Materials specified | Vol info | URL | Copy number | Status | Notes | Date due | Barcode | Item holds | Item hold queue priority | Course reserves | |
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Journal Article
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DOH Central Library Electronic Resource Section | J000642 (Browse shelf(Opens below)) | Available | D0001J000642 |
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Objective: The intracameral anesthesia is being used increasingly. These agents however may have toxic effects on the corneal endothelium. The purpose of the study is to determine whether the addition of preservative-free ropivacaine 0.2 percent, preservative-free ropivacaine 0.75 percent or preservative-free lidocaine 1 percent eyebank cornea preservative, Optisol, affects the endothelial cell count, hexagonality and pachymetry of human corneas.
Materials/Methodology: Human eyebank corneas were immersed in one of four solutions (Scorneas per group) namely control group (pure Optisol) or one of the three test group [1:1 mixture of Optisol plus preservative-free anesthetic (lidocaine 1 percent, ropivacaine 0.2 percent or ropivacaine 0.75 percent 0)]. Endothelial cell count, hexagonality and pachymetry were determined at baseline, 15, 30,45 and 60 minutes following exposure to these solutions. These values were then compared within and between groups using student's t test and one way ANOVA respectively. A p value of < 0.05 was considered statistically significant.
Results: Lidocaine 1 percent and ropivacaine 0.2 percent showed comparable toxic effects on the corneal endothelium. Ropivacaine 0.7.5 percent showed significantly more toxic effects than the other agents.
Conclusion: Compared to Lidocaine 1 percent, Ropivacaine 0.2 percent is equal to its toxicity profile on in its effect on the corneal endothelial cell count, hexagonality and pachymetry. (Author)
Makati Medical Center Proceedings, 2004 (18) pages 53-56
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