A randomized, blinded, placebo-controlled, pilot study on the effect of lyophilized bacterial extract on the hematopoietic recovery in immunosuppressed mice / Joey D. Borromeo [and two others]
Subject(s): Abstract: Chemotherapy, a mode of treatment for cancer patients renders depression of hematopoietic cells thus patients become more immunocompromised. When hematopoietic depression is severe, the use of colony-stimulating factors are advocated. However, due to their high cost, only few patients in our country benefit from its effect. Recent studies are centered in enhancing the patients own immune system to generate a response using immunomodulators/immunostimulators. A lyohilized bacterial extract (Broncho-Vaxom; BV) is an immunomodulating agent that is used in the treatment and prevention of recurrent respiratory tract infections. Its other uses had been explored using animal subjects. Recent studies on this drug is its readioprotective effect on irradiated mice. This randomized, blinded, placebo controlled study was conducted to evaluate the role of Broncho-Vaxom in the hematopoietic recovery of immunosuppressed mice. Immunosuppression was done by administering cyclophosphamide. Complete blood count and bone marrow aspirate were obtained to compare effect of BV from placebo treated mice. Results showed that BV does not have statistically significant effect on the acceleration of hematopoietic recovery in immunosuppressed mice.| Cover image | Item type | Current library | Home library | Collection | Shelving location | Call number | Materials specified | Vol info | URL | Copy number | Status | Notes | Date due | Barcode | Item holds | Item hold queue priority | Course reserves | |
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Journal Article
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DOH Central Library Electronic Resource Section | J000663 (Browse shelf(Opens below)) | Available | D0001J000663 |
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Chemotherapy, a mode of treatment for cancer patients renders depression of hematopoietic cells thus patients become more immunocompromised. When hematopoietic depression is severe, the use of colony-stimulating factors are advocated. However, due to their high cost, only few patients in our country benefit from its effect. Recent studies are centered in enhancing the patients own immune system to generate a response using immunomodulators/immunostimulators. A lyohilized bacterial extract (Broncho-Vaxom; BV) is an immunomodulating agent that is used in the treatment and prevention of recurrent respiratory tract infections. Its other uses had been explored using animal subjects. Recent studies on this drug is its readioprotective effect on irradiated mice. This randomized, blinded, placebo controlled study was conducted to evaluate the role of Broncho-Vaxom in the hematopoietic recovery of immunosuppressed mice. Immunosuppression was done by administering cyclophosphamide. Complete blood count and bone marrow aspirate were obtained to compare effect of BV from placebo treated mice. Results showed that BV does not have statistically significant effect on the acceleration of hematopoietic recovery in immunosuppressed mice.
Makati Medical Center Proceedings, 1999 (13) pages 89-96
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